Education [MSc/MD/PhD neuroscience] Promotion of young researchers Flow cytometry Brain imaging [from cell to system] Proteomik,Genomik, Genetik Research area A: Mechanisms of damage Research Area B: Endogenous brain protection Research area C: Regeneration Research area D: Crosstalk between nervous and immune system Research area E: Developmental disturbances Research area F: Plasticity Disorders of network formation Neuroinflammation Cerebro-vascular diseases (CVD) Research unit for long-term outcome and behavioral analysis Research unit for long-term outcome and behavioral analysis NeuroCure Clinical Research Center

     

     

     

     

     

     

     

     

     

     

     

     

     

     

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Research unit for long-term outcome
and behavioral analysis

For many decades, outcome assessment in preclinical models of neurological disorders was heavily biased towards quantifying morphology (e.g. infarct volumes, cell death, altered connectivity, cell-specific expression alterations, etc.). With the failure to translate promising neuroprotective strategies into clinical therapies, it was realized that it is highly important to measure experimental outcome in a more clinically relevant way (sensory, motor, cognitive, and behavioral function). It was also realized that the failure to translate preclinical studies into clinical practice is also due to missing studies on confounding factors such as age and comorbidity which at the same time may affect the capabilities of a given animal. On the other hand, clinically efficient therapies often do not work in animals due to different metabolic handling of drugs. We therefore set up a core unit within NeuroCure which will offer to all scientists in the cluster the possibility to study outcome in animal models of neurological disorders by establishing (1) behavior labs for mice and rats, (2) a microdialysis unit for monitoring of drug concentrations in studied animals, (3) a video EEG unit and a depth recording unit to monitor behavior in relation to EEG and local field potentials as well as neuronal activity. The unit will be supplemented by animal keeping space close by, (4) a surgery unit, and (5) a histology lab.