Research Area B:
Endogenous brain protection

Research on endogenous brain protection along with subsequent therapeutic exploitation of its signaling pathways is highly amenable to a joint effort of NeuroCure scientists focusing on diseases causing damage by the classical danger signals of hypoxia/ischemia, inflammation, and hyperexcitablity.

 

Our strategies will involve HIF-1 and erythropoietin-dependent protective pathways, preconditioning via endothelial nitric oxide synthase, multi-drug transporter targeting, and epigenetic modification. These therapeutic modalities open windows into endogenous neuroprotection and potentially, a window of opportunity to utilize these mechanisms in the clinic to treat patients with stroke and other CNS disorders.